THE RELATIONSHIP BETWEEN ESTRIOL, THE LITTLE ESTROGEN, INFLAMMATION AND THE TREATMENT OF CANCER 

By Dr. Bruce Frye

Esterone, Estradiol and Estriol are the three tri-estrogens. Esterone is considered to be the most potent and have the most severe effects on women by causing inflammation. Studies from the clinical endocrinology and metabolism state that initial studies on estrogen replacement found that oral pharmaceutical estrogen replacement did cause a reduction in lipoproteins. However their report further proves that over a 5 year study that oral pharmaceutical estrogen actually increased morbidity by causing thrombus formation and increasing CRP or c reactive protein, an inflammatory marker. The same study also showed that estradiol, the next most potent estrogen, also increased inflammation. Only the “little estrogen”, Estriol, has been found to not increase inflammation and in fact reduce it. Progesterone also reduces the inflammatory effects of esterone and estradiol.

The most cancer promoting of these estrogens are estradiol and esterone. (Encyclopedia .com) Progesterone has the opposite effect by inhibiting new cell growth. In order for estrogen to deliver its message to a tissue or cell, the cell membranes must have receptor sites that only estrogen or chemicals similar to estrogen will activate. Progesterone cannot occupy an estrogen receptor. All reproductive tissues have estrogen receptors including the breasts.

Inflammation causes a rise in PKB controlled responses. PKB is an enzyme the body produces to reduce inflammation. PKB also stimulates cell preservation and inhibits cellular apoptosis or cellular death which is necessary for the body to rid itself of cancer cells. With chronic inflammation the cellular preservation rate of cancerous cells goes unchecked and tumor development occurs.

High levels of esterone create the inflammation in the breast tissue setting up the increase in PKB controlled responses. PKB increases cellular growth and cellular survival. PKB itself is not the bad guy. It actually is an anti aging factor aiding in dissolving fat and increasing muscle tone. The problem is the chronic inflammation created by the high esterone and estradiol levels. They keep a chronic inflammatory state in the breasts. Have you ever had breast tenderness especially just before your menstrual cycle and been told it was because of too much estrogen?  This is inflammation in the breasts.  We all have abnormal cells that develop in our bodies. Under normal circumstances our body gets rid of them by the process of apoptosis as discussed above.  Now an enzyme (PKB) meant to keep us young and in good shape ends up blocking the cellular death of abnormal cells in the breast. Over time the abnormal cells then replicate creating a tumor or cancer.

Estriol the “little estrogen” does not create inflammation and therefore does not initiate cancer. In fact the “little estrogen” is anti-cancerous. Estrogen binding cites are specific for estrogen. Site(Townsend letter for doctors).

You cannot block estrogen with progesterone. Estrogen binding sites only accept estrogen. We must block estrogen with estrogen! We must block the cancerous esterone and estradiol with the anti-inflammatory anti-cancerous “little estrogen” estriol.

Estriol the good guy, the weaker estrogen, is like the phytoestrogen found in herbs and food. Phytoestrogens or plant estrogens are between 1/30 and 1/1000 times weaker than powerful esterone and estradiol. The weaker estrogens occupy the same binding receptor sites as the powerful estrogen would and thereby reducing the effects of estrogen on your body by 1/30 to 1/1000. In this case, having the receptor sites occupied by such a weak estrogen is truly the meaning of “a little is more”. The inflammatory response is resolved and the PKB enzymes get out of the breast and go back to getting rid of fat and aiding your strength and vitality as they should.

So what does this mean? First it means that synthetic estrogen hormone replacement causes cancer. Recently, the medical community has recognized this information and they have been directed to give synthetic hormones for only short-term use. Secondly, we are not getting enough of the Phytoestrogens in the diet. Eating oysters, cruciferous vegetables, including brussel sprouts, cabbage, cauliflower and especially broccoli, decrease estrogen levels. Vitamin K, (alfalfa and leafy green vegetables)

There are synthetic strong estrogens in steroid fed dairy cows. Milk and milk products as well as beef come from cows that are commonly fed steroids. There are chemicals that mimic the strong estrogens found in plastics and products packaged in plastics. In general our modern life gives an abundance of the strong estrogens that lead to cancer. It then becomes a must to focus to abstain from foods etc. known to contain the harmful estrogens, eat the foods that have the helpful hormones, but of equal or greater importance to focus on ingesting or rubbing into the skin the “little estrogens” like phytoestrogens. We do what we can with out diet and exposure. However, the prevalence of harmful estrogens is so strong that I believe each person must protect himself or herself, by taking the phytoestrogens like those found in certain herbs. Yes men can benefit by this in reducing prostate inflammation “prostatitis” and prostate cancer.

The bible says the herbs of the field are for our medicine and there are fantastic phytoestrogens available. One of the best is described by the bible in Song of Solomon.  “Myrrh my well beloved shall lie all night between my breasts until the darkness flees the light.” Is it any wonder why Myrrh (the phytoestrogen) is lying between the breasts? Is darkness representing cancer fleeing the light? For women with breast cancer and those who want to prevent it, definitely.

Lastly, we cannot resolve the issue by simply increasing progesterone, while it helps to mitigate the effects of estrogen it cannot bind the estrogen receptor sites where the problem begins. Only a “little estrogen” can bind estrogen sites and block the harmful estrogens from initiating the inflammatory response and cancerous environment.

                                          Gold Frankincense and Myrrh

The Scientific evidence of a “Miracle Formula” from the Bible.
Biblically, Gold Frankincense and Myrrh was given to Christ at his birth. It was esteemed higher and cost more than pure gold.  Frankincense is considered the ‘holy anointing oil” and well known for its healing powers for centuries. Myrrh is referenced Biblically as purifying oil for women. Esther 2:12 Biblically these herbs are well documented however, Dr. Frye has been given revelation on scripture concerning the uses of Frankincense and Myrrh and will offer scientific evidence of its actions proving not only the scripture but giving even further indications of its incredible importance in your health today.

Mathew 2:11 “…And when they were come into the house, they saw the young child with Mary His mother…and when they had opened their treasures, they presented unto Him gifts: gold, frankincense, and myrrh”

Song of Solomon1:13 “A bundle of myrrh {is} my well beloved unto me: he shall lie all night betwixt my breasts”

Song of Solomon 4:5-6 Thy two breasts are like two young roes……Until the day break, and the shadows flee away, I will get me to the mountain of myrrh and to the hill of frankincense.

In these scriptures we see the reference to gold, frankincense and myrrh as a great treasure or gift as well as a constant reference of frankincense and myrrh to the breasts.

Is there any scientific relationship to the breasts and these herbs?
Myrrh is cited by the PDR of essential oils as being hormone like. Additional studies have been done on Myrrh’s hormone like capability. Breast Cancer is known to be an estrogen fed cancer. There is however a difference in estrogens. Studies show that the weaker phyto estrogens like myrrh do not increase tumor growth and in fact, being hormone like are able to bind to estrogen receptor cites and block the stronger or toxic estrogen from causing tumor growth. In addition, the body recognizes the presence of the phyto estrogen (Myrrh) and reduces its own production of estrogen.

In the scripture what is reference to “the shadows fleeing away?”
Not only is this referring to the day light coming but notice that these shadows are fleeing away. Darkness fleeing away is symbolic in many different ways; first darkness can be darkness of the mind or depression. Secondly, darkness can refer to sickness or even cancer.

Do Frankincense and Myrrh have any effect on depression?
Scientific evidence of Myrrh’s affect on the hormonal regulation and the depression and mood swings that come with hormone imbalance are well documented. As stated Myrrh is hormone like. Myrrh as a phyto-estrogen is accepted by the body and will fill estrogen receptor cites. An estrogen deficient woman will receive the benefit of the phyto estrogen and the hormone balance it provides. A woman deficient in progesterone is essentially a woman with too much of the stronger (toxic) estrogen. If there is too much of the stronger estrogen in the body, the phyto-estrogens influx will cause a lowering of the production of estrogen and allow the relative progesterone levels to increase. This unique capability of Myrrh, gives it the label of an adaptogen with the capability to balancing the hormones and the mood swings that come with it. In addition, Frankincense and Myrrh aroma affects the limbic system that influences mood.

What about the darkness of cancer? Could the darkness of cancer flee from Frankincense and Myrrh?

Frankincense again is cited by the PDR of essential oils as being anti tumoral.  However, is there any scientific evidence that Frankincense aids in the fight against cancer?
Terpenes are a major chemical constituent of Frankincense. Scientific studies on Terpenes have revealed that they are cytotoxic, (toxic to cancer cells). Further evidence suggests that Frankincense will cross the blood brain barrier which means that it is an excellent carrier oil and can have its anti tumoral effects throughout the body. One of the difficulties in treating cancer is that the cancerous cell has a defective cellular respiration and cell wall transport system.  Frankincense having the ability to cross the blood brain barrier is an excellent carrier of the cytotoxic terpenes across the cancer cell barrier. This process is much like a natural chemo treatment. Researchers state that the terpenes and sesquiterpenes in Myrrh and Frankincense are in food and are likely to not be toxic to normal cells.

Myrrh is also an anti-cancer agent. A specific species of Myrrh was tested against a human breast tumor cell line (MCF-7) known to be resistant to anticancer drugs. Research data indicated that the extract of Myrrh killed all the cancer cells in laboratory dishes. Further investigations found that myrrh killed cancer cells by inactivation a specific protein, called Bcl-2, which is over produced by the breast and prostate. Overproduction of this protein makes cancer cells more resistant to chemotherapy. This gives rise to the possibility not only of Frankincense and Myrrh being a wonderful God given cancer treatment but also in aiding those, which choose chemotherapy as well. This also gives evidence to the benefit of Frankincense and Myrrh in cancer of the prostate as well as breast.

Another group of anti-cancer drugs are being developed using the anti-inflammatory effect of blocking the actyl co-A enzyme, which results in the deactivation of PKB-AKT kinase enzyme. The result is to remove the growth factor, which can stimulate tumor growth and thereby induce apoptosis (cellular death) of cancer cells. Myrrh’s terpene chemistry has been researched and found to be an anti-inflammatory, which also blocks actyl-co A enzyme and therefore the growth factor for cancer. Another potent blocker of the enzyme growth factor and stimulator of apoptosis (cancer cell death) is Cummin. Cummin could also be an important aid in the fight against cancer.

What about gold?  Does it have any anti-cancer effects?
Gold attaches to albumin in the blood stream and undergoes thyol exchange reactions then is absorbed into the cells.  Once absorbed into the cell, gold is proposed to be linked to anti-mitochrondrail activity and thereby induces cell apoptosis or cellular death of cancer cells.

Gold is also currently being used in cancer treatment with radio frequency waves. 

How would you use Frankincense and Myrrh?
Dr. Frye was given further revelation that the Bible actually gives us the correct formula to use with Frankincense and Myrrh! The scripture reads “….a mountain of myrrh and to the hill of frankincense” We are given the relative doses of a large (mountain) amount of myrrh and a smaller (hill) of frankincense in addition to the treatment directions which are to be applied topically at bedtime.